Scholarlink

Purpose <p>To examine how county-level obesity status affects early-onset colorectal cancer (EOCRC) survival across racial groups and survival timeframes in Georgia.</p> Methods <p>We conducted a retrospective cohort study using data from the 2010 to 2020 Georgia Cancer Registry, linked with County Health Rankings. The primary exposures were race/ethnicity and county-level obesity rates. Outcomes were survival time from diagnosis to 12, 36, and 60&#xa0;months. Traditional and piecewise Cox regression models were used.</p> Results <p>Among 6291 patients, 63.4% lived in high-obesity areas, and 53.3% were White patients. White patients living in high-obesity areas had significantly lower 3-year (76.6% vs 81.1%;&#xa0;<i>p</i> = 0.002) and 5-year (71.3% vs 75.7%; <i>p</i> = 0.001) survival rates. Adjusted analysis showed that patients living in high-obesity areas were 14% more likely to die from CRC than those not living in these areas at both 3- (95% CI, 1.02–1.28) and 5-year (95% CI, 1.03–1.27) intervals, whereas White patients specifically were 32% (95% CI, 1.11–1.54) and 33% (95% CI, 1.13–1.50) more likely to die from CRC. Piecewise models revealed a 29% increased risk of CRC mortality within 1–3&#xa0;years (95% CI, 1.11–1.50), with subgroup analysis showing an even higher 51% risk for White patients during the same interval (95% CI, 1.21–1.89).</p> Conclusions <p>Findings suggest that mortality risk varies over time, with elevated risk in the first 1–3&#xa0;years for White patients in high-obesity areas. Targeted efforts aimed at promoting healthy lifestyles and investing in community resources that foster healthier living may reduce early mortality.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Multilevel insights into obesity, race/ethnicity, and survival in early-onset colorectal cancer in Georgia

  • 期刊论文

  • 发表日期：

    2026年5月26日

查看全文
  • Meng-Han Tsai,
  • Marlo Vernon,
  • Malcolm Bevel,
  • Parmida Jamshidi,
  • Jorge Cortes,
  • Aaron Kruse-Diehr

摘要

Purpose

To examine how county-level obesity status affects early-onset colorectal cancer (EOCRC) survival across racial groups and survival timeframes in Georgia.

Methods

We conducted a retrospective cohort study using data from the 2010 to 2020 Georgia Cancer Registry, linked with County Health Rankings. The primary exposures were race/ethnicity and county-level obesity rates. Outcomes were survival time from diagnosis to 12, 36, and 60 months. Traditional and piecewise Cox regression models were used.

Results

Among 6291 patients, 63.4% lived in high-obesity areas, and 53.3% were White patients. White patients living in high-obesity areas had significantly lower 3-year (76.6% vs 81.1%; p = 0.002) and 5-year (71.3% vs 75.7%; p = 0.001) survival rates. Adjusted analysis showed that patients living in high-obesity areas were 14% more likely to die from CRC than those not living in these areas at both 3- (95% CI, 1.02–1.28) and 5-year (95% CI, 1.03–1.27) intervals, whereas White patients specifically were 32% (95% CI, 1.11–1.54) and 33% (95% CI, 1.13–1.50) more likely to die from CRC. Piecewise models revealed a 29% increased risk of CRC mortality within 1–3 years (95% CI, 1.11–1.50), with subgroup analysis showing an even higher 51% risk for White patients during the same interval (95% CI, 1.21–1.89).

Conclusions

Findings suggest that mortality risk varies over time, with elevated risk in the first 1–3 years for White patients in high-obesity areas. Targeted efforts aimed at promoting healthy lifestyles and investing in community resources that foster healthier living may reduce early mortality.