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Purpose <p>Cancer-related cognitive impairment (CRCI) is a common concern among breast cancer (BC) patients receiving chemotherapy, yet predictors of short-term cognitive change remain unclear. This study examined whether baseline cardiorespiratory fitness (CRF) and moderate-to-vigorous physical activity (MVPA) moderate changes in objectively assessed cognitive function from pre- to post-chemotherapy in BC patients, compared with age-matched healthy controls.</p> Methods <p>This prospective study included assessments at baseline (pre-chemotherapy) and approximately a five-month follow-up (post-chemotherapy). Participants were BC patients with stage I–III disease initiating chemotherapy and age-matched healthy controls. Cognitive function was assessed using the NIH Remote Cognition Toolbox (episodic memory, working memory, language/reading, verbal learning). CRF was measured using a remotely administered 6-min walk test, and MVPA was assessed via accelerometry. Linear mixed-effects models tested group × time × predictor (baseline CRF or MVPA) effects, adjusting for anxiety, depression, and menopausal status.</p> Results <p>Fifty-five participants were included (BC: <i>n</i> = 32; controls: <i>n</i> = 23). Episodic memory improved over time in both groups (β = 4.69, <i>p</i> = 0.031). Higher baseline CRF was associated with better verbal learning (β = 0.02, <i>p</i> = 0.023), but neither CRF nor MVPA predicted cognitive change over time (all three-way interactions <i>p</i> ≥ 0.05). BC patients scored lower than controls at baseline on working memory and language/reading, while verbal learning improved more in BC patients. BC patients also showed greater declines in MVPA over time.</p> Findings <p>No short-term cognitive decline was observed from pre-chemotherapy to approximately 5&#xa0;months post-chemotherapy. Higher baseline fitness and physical activity were associated with better cognitive performance but did not predict cognitive change. Longer follow-up is needed to clarify treatment-related cognitive trajectories.</p>

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Longitudinal associations of cardiorespiratory fitness and physical activity with changes in cognitive function in breast cancer patients undergoing chemotherapy: a prospective matched-control study

  • 期刊论文

  • 发表日期：

    2026年4月15日

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  • Hui Xiao,
  • Ellen Warner,
  • Jennifer Ryan,
  • Catherine Sabiston,
  • Golnaz Ghazinour,
  • Sarah O’Rourke,
  • Daniel Moore,
  • Timothy Welsh,
  • Linda Trinh

摘要

Purpose

Cancer-related cognitive impairment (CRCI) is a common concern among breast cancer (BC) patients receiving chemotherapy, yet predictors of short-term cognitive change remain unclear. This study examined whether baseline cardiorespiratory fitness (CRF) and moderate-to-vigorous physical activity (MVPA) moderate changes in objectively assessed cognitive function from pre- to post-chemotherapy in BC patients, compared with age-matched healthy controls.

Methods

This prospective study included assessments at baseline (pre-chemotherapy) and approximately a five-month follow-up (post-chemotherapy). Participants were BC patients with stage I–III disease initiating chemotherapy and age-matched healthy controls. Cognitive function was assessed using the NIH Remote Cognition Toolbox (episodic memory, working memory, language/reading, verbal learning). CRF was measured using a remotely administered 6-min walk test, and MVPA was assessed via accelerometry. Linear mixed-effects models tested group × time × predictor (baseline CRF or MVPA) effects, adjusting for anxiety, depression, and menopausal status.

Results

Fifty-five participants were included (BC: n = 32; controls: n = 23). Episodic memory improved over time in both groups (β = 4.69, p = 0.031). Higher baseline CRF was associated with better verbal learning (β = 0.02, p = 0.023), but neither CRF nor MVPA predicted cognitive change over time (all three-way interactions p ≥ 0.05). BC patients scored lower than controls at baseline on working memory and language/reading, while verbal learning improved more in BC patients. BC patients also showed greater declines in MVPA over time.

Findings

No short-term cognitive decline was observed from pre-chemotherapy to approximately 5 months post-chemotherapy. Higher baseline fitness and physical activity were associated with better cognitive performance but did not predict cognitive change. Longer follow-up is needed to clarify treatment-related cognitive trajectories.