Impact of a guaranteed access program to imatinib on the survival of patients with chronic myeloid leukemia

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发表日期：

2024年9月10日

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Gilberto Barranco,
Itzel Vidal,
Dulce Gama,
Carlos Martínez,
Brenda Acosta,
Christian Ramos,
Emmanuel Martínez,
Juan Zazueta,
Irma Olarte,
Adolfo Martínez,
Eduardo Cervera,
Iveth Mendoza,
Diana Arcos,
Judith Cruz

摘要

Purpose

This work aimed to evaluate the impact of a guaranteed access program to imatinib on the survival of patients with Chronic Myeloid Leukemia.

Methods

We carried out a retrospective, observational, and analytical study of the database of patients diagnosed with Chronic Myeloid Leukemia of the Instituto Nacional de Cancerología and the Hospital General de México Dr. Eduardo to assess overall survival based on guaranteed access or not to imatinib.

Results

With an average follow-up of 99 months, all patients’ estimated 20-year overall survival was 72% (95% CI, 76–67). A significant difference was found in the 20-year survival probability in favor of patients with guaranteed access 76% (95% CI, 81–71) vs. 61% (95% CI, 69–52) (p < 0.001), in addition to those in which they had better attachment 81.2% (95% CI, 85–76) vs. 44.9% (95% CI, 52–37) (p < 0.001).

Conclusion

CML is the most frequent chronic leukemia in Mexico. It mainly affects the economically active population (mean age 40), and the prognosis in our country has improved, emulating developed countries; however, the results depend on access to treatment and proper monitoring.