Clinical characteristics of male patients with breast cancer in the Latino population

期刊论文
发表日期：

2024年10月29日

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Carlos González-Nuñez,
Alejandro Mohar,
Nancy Reynoso-Noverón,
Rosa María Alvarez-Gómez,
Yanin Chavarri-Guerra,
Sergio Aguilar-Villanueva,
Raúl Guzmán-Trigueros,
Areli Velázquez-Martínez,
Talía Wegman-Ostrosky,
Fanny Porras-Reyes,
Alexandra Garcilazo,
Claudia Arce,
Juan Enrique Bargallo-Rocha,
Paula Cabrera-Galeana

摘要

Purpose

Breast cancer is the most prevalent cancer type in Mexico, with male breast cancer accounting for only 1% of all breast cancer cases. A limited number of studies have described the clinical-pathological profiles of males with breast cancer in low- and middle-income countries. This study presents an analysis of patients with breast cancer seen at three different institutions in México.

Methods

A retrospective review of the medical records was performed to analyze the clinical and pathological characteristics of 49 men diagnosed with breast cancer and their overall survival.

Results

The mean age at diagnosis was 64.65 years. A significant proportion of patients presented at diagnosis with stage IV disease (n = 11, 22.45%), had triple-negative subtype (n = 6, 12.24%), and nuclear grade III (n = 20, 40.8%). Primary endocrine resistance was observed in 10 patients (31.25%). Genetic analysis was performed on 24 patients (48.9%), revealing a germline BRCA pathogenic variant in 8.33%.

Conclusion

Our findings described the clinical and pathological profile of breast cancer in a male cohort in Mexico, with a significantly high proportion of advanced disease, triple-negative subtype, nuclear grade III, and endocrine resistance. Further comprehensive studies, including research into somatic mutations, are needed.