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<p>Localized surface plasmon resonance (LSPR) sensors have good potential for label-free non-invasive detection of biomolecules, healthcare diagnosis, disease monitoring, gas sensing, and food safety. For detection of low concentration small-sized bioanalytes (e.g., viruses, proteins, etc) the plasmonic field needs to be localized on a larger device surface area. Our study focuses on the optimization and fabrication of leaky Au nanoresonators based sensing platform for SARS-CoV-2 detection with uniform sensitivity over a 100 <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\mu\)</EquationSource> </InlineEquation>m <InlineEquation ID="IEq2"> <EquationSource Format="TEX">\(\times\)</EquationSource> </InlineEquation> 100 <InlineEquation ID="IEq3"> <EquationSource Format="TEX">\(\mu\)</EquationSource> </InlineEquation>m active sensing area. The Au nanoresonator array was optimized to detect 100 nm sized bioanalytes as it matches the size of SARS-CoV-2. The performance of the optimized design was tested with 100 nm sized polystyrene beads which demonstrated a sensitivity of 17.05 ± 3.25 nm/decade. The Au nanoresonators were functionalized with anti-SARS-CoV-2 antibody to detect SARS-CoV-2. Our experimental results demonstrate the best detection sensitivity of 1.32 ± 0.08 nm/decade and limit of detection of 1 VLP <InlineEquation ID="IEq4"> <EquationSource Format="TEX">\(\mu\)</EquationSource> </InlineEquation>L<InlineEquation ID="IEq5"> <EquationSource Format="TEX">\(^{-1}\)</EquationSource> </InlineEquation>.</p>

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Ultra-low detection of SARS-CoV-2 Virus Like Particles (VLPs) with functionalized gold plasmonic nanoresonator array

  • 期刊论文

  • 发表日期：

    2025年10月27日

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  • Dipanjan Nandi,
  • Jiaxin Fan,
  • Seongdae Kang,
  • Manisha Gupta

摘要

Localized surface plasmon resonance (LSPR) sensors have good potential for label-free non-invasive detection of biomolecules, healthcare diagnosis, disease monitoring, gas sensing, and food safety. For detection of low concentration small-sized bioanalytes (e.g., viruses, proteins, etc) the plasmonic field needs to be localized on a larger device surface area. Our study focuses on the optimization and fabrication of leaky Au nanoresonators based sensing platform for SARS-CoV-2 detection with uniform sensitivity over a 100 \(\mu\) m \(\times\) 100 \(\mu\) m active sensing area. The Au nanoresonator array was optimized to detect 100 nm sized bioanalytes as it matches the size of SARS-CoV-2. The performance of the optimized design was tested with 100 nm sized polystyrene beads which demonstrated a sensitivity of 17.05 ± 3.25 nm/decade. The Au nanoresonators were functionalized with anti-SARS-CoV-2 antibody to detect SARS-CoV-2. Our experimental results demonstrate the best detection sensitivity of 1.32 ± 0.08 nm/decade and limit of detection of 1 VLP \(\mu\) L \(^{-1}\) .