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<p>Methylmercury (MeHg) contamination can cause damage to the salivary glands, which is associated with oxidative stress and glandular dysfunction. Açaí (<i>Euterpe oleracea</i> Martius), a fruit rich in antioxidants, emerges as a natural alternative to mitigate the toxic effects of MeHg. This study aimed to evaluate whether clarified açaí juice exerts a protective effect on the major salivary glands of rats intoxicated with MeHg. Wistar rats were allocated into four groups: control, MeHg-exposed (0.04&#xa0;mg/kg/day), açaí-supplemented (0.01&#xa0;L/kg/day), and MeHg-exposed with açaí&#xa0;supplementation. The compounds were administered by orogastric gavage for 60&#xa0;days. Subsequently, total saliva was collected to determine antioxidant capacity, lipid peroxidation, and amylase activity, while submandibular and parotid glands were analyzed to total mercury (Hg) levels, antioxidant capacity, and lipid peroxidation. Our results showed that açaí supplementation did not reduce Hg accumulation in the salivary glands. However, MeHg exposure significantly decreased antioxidant capacity in both glands, whereas açaí supplementation mitigated this reduction, maintaining values comparable to the control group. Lipid peroxidation was elevated in the MeHg group in both glands, but this alteration was attenuated by açaí. In saliva, MeHg exposure lowered antioxidant capacity and elevated lipid peroxidation levels, both of which were attenuated by açaí supplementation. Moreover, MeHg altered salivary protein concentration and reduced amylase activity, while açaí supplementation counteracted these effects. These results demonstrate that açaí’s antioxidant constituents confer protective effects against MeHg-induced oxidative damage and functional impairment in salivary glands and saliva, underscoring its potential as a natural protective agent against Hg toxicity.</p>

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Clarified açaí (Euterpe oleracea Martius) exerts protective effects against methylmercury toxicity in salivary glands and total saliva

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月20日

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  • Vinicius Ruan Neves dos Santos,
  • Leonardo Oliveira Bittencourt,
  • Hadassa Helez Neves Ferreira,
  • Daiane Claydes Baia-da-Silva,
  • Paulo Fernando Santos Mendes,
  • Luis Eduardo de Oliveira Teixeira,
  • Antonio Hernandes Chaves-Neto,
  • Bruno Santana Carneiro,
  • Diomar Cavalcante Oliveira,
  • Iracina Maura de Jesus,
  • Renata Duarte de Souza-Rodrigues,
  • Herve Rogez,
  • Rafael Rodrigues Lima

摘要

Methylmercury (MeHg) contamination can cause damage to the salivary glands, which is associated with oxidative stress and glandular dysfunction. Açaí (Euterpe oleracea Martius), a fruit rich in antioxidants, emerges as a natural alternative to mitigate the toxic effects of MeHg. This study aimed to evaluate whether clarified açaí juice exerts a protective effect on the major salivary glands of rats intoxicated with MeHg. Wistar rats were allocated into four groups: control, MeHg-exposed (0.04 mg/kg/day), açaí-supplemented (0.01 L/kg/day), and MeHg-exposed with açaí supplementation. The compounds were administered by orogastric gavage for 60 days. Subsequently, total saliva was collected to determine antioxidant capacity, lipid peroxidation, and amylase activity, while submandibular and parotid glands were analyzed to total mercury (Hg) levels, antioxidant capacity, and lipid peroxidation. Our results showed that açaí supplementation did not reduce Hg accumulation in the salivary glands. However, MeHg exposure significantly decreased antioxidant capacity in both glands, whereas açaí supplementation mitigated this reduction, maintaining values comparable to the control group. Lipid peroxidation was elevated in the MeHg group in both glands, but this alteration was attenuated by açaí. In saliva, MeHg exposure lowered antioxidant capacity and elevated lipid peroxidation levels, both of which were attenuated by açaí supplementation. Moreover, MeHg altered salivary protein concentration and reduced amylase activity, while açaí supplementation counteracted these effects. These results demonstrate that açaí’s antioxidant constituents confer protective effects against MeHg-induced oxidative damage and functional impairment in salivary glands and saliva, underscoring its potential as a natural protective agent against Hg toxicity.