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<p>Vanadium complexes featuring 8-hydroxyquinoline ligands and their derivatives have emerged as a promising class of compounds with potential therapeutic applications, particularly as antimicrobial and anticancer agents. This comprehensive review offers a timely and insightful analysis of the current landscape of vanadium complexes with HQ ligand or its derivatives, whether alone or in combination with organic coligands. This review covers synthetic strategies, and mechanisms that underlie their antibacterial and anticancer activities. A significant focus of this review is the thorough evaluation of the antibacterial and anticancer properties of these complexes, providing an invaluable resource for researchers in the interdisciplinary fields of inorganic chemistry, medicinal chemistry, and drug discovery. By compiling and synthesizing the existing knowledge on vanadium-8-hydroxyquinoline (VO-8HQ) complexes, this review addresses a critical gap in the literature. Ongoing research, including rigorous preclinical and clinical evaluations, is essential for fully exploring the therapeutic potential of this promising class of metallodrugs.</p>

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Vanadium 8-hydroxyquinoline derivatives in medicine: current state and future outlook

  • 期刊论文

  • 发表日期：

    2025年5月6日

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  • Tahmineh Kohanfekr,
  • Camelia Gholamrezazadeh,
  • Hasan Ali Hosseini

摘要

Vanadium complexes featuring 8-hydroxyquinoline ligands and their derivatives have emerged as a promising class of compounds with potential therapeutic applications, particularly as antimicrobial and anticancer agents. This comprehensive review offers a timely and insightful analysis of the current landscape of vanadium complexes with HQ ligand or its derivatives, whether alone or in combination with organic coligands. This review covers synthetic strategies, and mechanisms that underlie their antibacterial and anticancer activities. A significant focus of this review is the thorough evaluation of the antibacterial and anticancer properties of these complexes, providing an invaluable resource for researchers in the interdisciplinary fields of inorganic chemistry, medicinal chemistry, and drug discovery. By compiling and synthesizing the existing knowledge on vanadium-8-hydroxyquinoline (VO-8HQ) complexes, this review addresses a critical gap in the literature. Ongoing research, including rigorous preclinical and clinical evaluations, is essential for fully exploring the therapeutic potential of this promising class of metallodrugs.