<p>Environmental pollution caused by persistent organic pollutants poses a significant global threat due to their toxicity and tendency to accumulate in ecosystems. Microbial biodegradation offers a sustainable alternative to conventional remediation strategies. Among degradative microorganisms, the genus <i>Ochrobactrum</i> has gained attention for its metabolic versatility and ability to transform a wide range of xenobiotic compounds. This review comprehensively examines genus <i>Ochrobactrum</i>, focusing on its species diversity, pollutant-degrading capabilities, and the biochemical pathways underlying these transformations. The genetic basis for enzyme production involved in degradation is highlighted, and organic pollutants are categorized according to their chemical class with corresponding species, and reported degradation rates.</p> Graphical abstract <p></p>