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<p>Arctigenin, a high-value lignan with broad bioactivities, suffers from low yield in conventional extraction. This study developed a green and efficient process integrating natural deep eutectic solvent (NADES)-pretreated&#xa0;<i>Aspergillus niger</i>&#xa0;fermentation with ultrasound-assisted extraction. Under optimized conditions (liquid–solid ratio 26:1 mL/g, 38 h fermentation, pH 5.6, 430 W ultrasound at 58&#xa0;°C, 42% NADES water content), the arctigenin yield reached 54.91 mg/g, 14.64-fold higher than in the raw herb (3.75 mg/g). NADES enhanced fungal growth, membrane permeability, and extracellular enzyme activity, facilitating bioconversion and extraction. This strategy effectively overcomes limitations of low arctigenin content and poor extraction efficiency, offering a promising approach for producing rare herbal compounds and insight into NADES-assisted whole-cell catalysis.</p>

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Ultrasonic high efficiency preparation of arctigenin from the fruits of Arctium lappa L using Aspergillus niger with deep eutectic solvent assisted

  • 期刊论文

  • 发表日期：

    2025年11月4日

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  • Yubin Ren,
  • Shuang Jin,
  • Weili Liu,
  • Cailiang Peng,
  • Hongyao Cai,
  • Huayong Zhao,
  • Yupeng Cheng,
  • Yujie Fu,
  • Na Zhang,
  • Siyuan Wang,
  • Chen Lv

摘要

Arctigenin, a high-value lignan with broad bioactivities, suffers from low yield in conventional extraction. This study developed a green and efficient process integrating natural deep eutectic solvent (NADES)-pretreated Aspergillus niger fermentation with ultrasound-assisted extraction. Under optimized conditions (liquid–solid ratio 26:1 mL/g, 38 h fermentation, pH 5.6, 430 W ultrasound at 58 °C, 42% NADES water content), the arctigenin yield reached 54.91 mg/g, 14.64-fold higher than in the raw herb (3.75 mg/g). NADES enhanced fungal growth, membrane permeability, and extracellular enzyme activity, facilitating bioconversion and extraction. This strategy effectively overcomes limitations of low arctigenin content and poor extraction efficiency, offering a promising approach for producing rare herbal compounds and insight into NADES-assisted whole-cell catalysis.