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Objective <p>This study aimed to prepare oxygen-microbubbles incorporating ferrous porphyrin to emulate the oxygen-capturing ability of hemoglobin porphyrin in red blood cells.</p> Results <p>We synthesized poly(2-hydroxyethyl aspartamide) (PHEA) grafted with ferrous porphyrins (Iron-P-PHEA) and created microbubbles using 1,2-dipalmitoyl-sn-glycero-3-phosphocholine. These microbubbles trapped oxygen and retained it over a 2&#xa0;h period. The O<sub>2</sub>-microbubbles demonstrated an enhanced photoacoustic effect as an ultrasound contrast agent, as confirmed by Doppler ultrasound testing.</p> Conclusions <p>The innovative strategy for O<sub>2</sub>-microbubble preparation enhances the efficiency of targeted delivery in molecular optical and ultrasound imaging.</p>

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O2-microbubble of iron-porphyrin conjugated polyaspartamide for molecular ultrasound contrast effect

  • 期刊论文

  • 发表日期：

    2025年2月19日

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  • Yoon Na Cho,
  • Jun Woo Lim,
  • Seung Joo Oh,
  • Sa Ra Han,
  • Sungwoo Cho,
  • Jimin Jeong,
  • Byoung Hee Han,
  • Jae Hyun Jeong

摘要

Objective

This study aimed to prepare oxygen-microbubbles incorporating ferrous porphyrin to emulate the oxygen-capturing ability of hemoglobin porphyrin in red blood cells.

Results

We synthesized poly(2-hydroxyethyl aspartamide) (PHEA) grafted with ferrous porphyrins (Iron-P-PHEA) and created microbubbles using 1,2-dipalmitoyl-sn-glycero-3-phosphocholine. These microbubbles trapped oxygen and retained it over a 2 h period. The O2-microbubbles demonstrated an enhanced photoacoustic effect as an ultrasound contrast agent, as confirmed by Doppler ultrasound testing.

Conclusions

The innovative strategy for O2-microbubble preparation enhances the efficiency of targeted delivery in molecular optical and ultrasound imaging.