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<p>This study evaluates the C-reactive protein-albumin-lymphocyte (CALLY) index for predicting multiple organ failure syndrome (MOFS) in elderly with sepsis (SP) through a retrospective analysis of 209 cases stratified by severity into SP, severe SP (SSP), and septic shock (SPS) groups. Patients were further categorized into MOFS and N-MOFS groups according to 30-day ICU outcomes. Correlations of CALLY index with APACHE II and SOFA scores were assessed using Spearman’s correlation analysis, while predictive utility was evaluated via ROC and Kaplan-Meier curves and Cox regression. Results demonstrated a progressive decline in CALLY index with worsening severity (SPS &lt; SSP &lt; SP; <i>P</i> &lt; 0.001), alongside negative correlations with APACHE II and SOFA scores (<i>P</i> &lt; 0.001). Patients who developed MOFS exhibited a significantly lower CALLY index than their N-MOFS counterparts (<i>P</i> &lt; 0.05). The index achieved superior MOFS prediction (AUC = 0.892) compared to APACHE II (AUC = 0.772; <i>P</i> &lt; 0.001) and SOFA (AUC = 0.815; <i>P</i> = 0.042), with low-CALLY patients showing higher cumulative MOFS incidence (<i>P</i> &lt; 0.001). Multivariate analysis confirmed elevated SOFA as an independent risk factor for MOFS, while higher CALLY index conferred protective effects, establishing this novel index as a robust predictor of MOFS that inversely correlates with SP severity in elderly.</p> Graphical Abstract <p></p>

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Predictive Value of C-Reactive Protein-Albumin-Lymphocyte Index for Multiple Organ Failure Syndrome in Elderly Patients with Sepsis

  • 期刊论文

  • 发表日期：

    2025年11月26日

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  • Zheng Fan,
  • Yuanyuan Zhang,
  • Shenglan Liu,
  • Hua Xu,
  • Yanxia Guo

摘要

This study evaluates the C-reactive protein-albumin-lymphocyte (CALLY) index for predicting multiple organ failure syndrome (MOFS) in elderly with sepsis (SP) through a retrospective analysis of 209 cases stratified by severity into SP, severe SP (SSP), and septic shock (SPS) groups. Patients were further categorized into MOFS and N-MOFS groups according to 30-day ICU outcomes. Correlations of CALLY index with APACHE II and SOFA scores were assessed using Spearman’s correlation analysis, while predictive utility was evaluated via ROC and Kaplan-Meier curves and Cox regression. Results demonstrated a progressive decline in CALLY index with worsening severity (SPS < SSP < SP; P < 0.001), alongside negative correlations with APACHE II and SOFA scores (P < 0.001). Patients who developed MOFS exhibited a significantly lower CALLY index than their N-MOFS counterparts (P < 0.05). The index achieved superior MOFS prediction (AUC = 0.892) compared to APACHE II (AUC = 0.772; P < 0.001) and SOFA (AUC = 0.815; P = 0.042), with low-CALLY patients showing higher cumulative MOFS incidence (P < 0.001). Multivariate analysis confirmed elevated SOFA as an independent risk factor for MOFS, while higher CALLY index conferred protective effects, establishing this novel index as a robust predictor of MOFS that inversely correlates with SP severity in elderly.

Graphical Abstract