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<p>Hepatocarcinogenesis is associated with various factors, including oxidative stress. Alterations in selenoprotein genes could impair redox balance and influence cancer development. In this study, we aimed to evaluate the association of single nucleotide variants (SNVs) from selenoproteins with hepatocellular carcinoma risk. The case and healthy groups were genotyped using quantitative polymerase chain reaction (qPCR), and the analyzed SNVs were rs1050450 and rs3448 <i>GPX1</i>, rs713041 <i>GPX4</i>, rs5845 and rs5859 <i>SEP15</i>, and rs7579 and rs3877899 <i>SELENOP</i>. Significant differences in genotype frequencies were observed between the case and healthy groups (<i>p</i> &lt; 0.05) for all studied SNVs, except for <i>GPX1</i> rs3448. Furthermore, G/G rs1050450 <i>GPX1</i> (<i>OR</i> = 1.975; 95% CI 1.075–3.628; <i>p</i> = 0.028) and homozygous C/C rs7579 <i>SELENOP</i> (<i>OR</i> = 3.088; 95% CI 1.667–5.722; <i>p</i> &lt; 0.001) were associated with an increased risk of hepatocellular carcinoma. Comparisons with 1000 Genomes Project data revealed genotype frequencies similar to those of European descendants. These results could suggest a role of genetic alterations of selenoproteins in hepatocellular carcinoma risk.</p>

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Evaluation of the Variability in Selenoprotein Genes in Hepatocellular Carcinoma Patients

  • 期刊论文

  • 发表日期：

    2025年8月12日

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  • Andressa de Freitas Alves,
  • Vanessa Dido Baldissera,
  • Tatiane Jacobsen da Rocha,
  • Carlos Thadeu Schmidt Cerski,
  • Paulo Ott Fontes,
  • Márcia Giovenardi,
  • Marilu Fiegenbaum,
  • Silvana Almeida

摘要

Hepatocarcinogenesis is associated with various factors, including oxidative stress. Alterations in selenoprotein genes could impair redox balance and influence cancer development. In this study, we aimed to evaluate the association of single nucleotide variants (SNVs) from selenoproteins with hepatocellular carcinoma risk. The case and healthy groups were genotyped using quantitative polymerase chain reaction (qPCR), and the analyzed SNVs were rs1050450 and rs3448 GPX1, rs713041 GPX4, rs5845 and rs5859 SEP15, and rs7579 and rs3877899 SELENOP. Significant differences in genotype frequencies were observed between the case and healthy groups (p < 0.05) for all studied SNVs, except for GPX1 rs3448. Furthermore, G/G rs1050450 GPX1 (OR = 1.975; 95% CI 1.075–3.628; p = 0.028) and homozygous C/C rs7579 SELENOP (OR = 3.088; 95% CI 1.667–5.722; p < 0.001) were associated with an increased risk of hepatocellular carcinoma. Comparisons with 1000 Genomes Project data revealed genotype frequencies similar to those of European descendants. These results could suggest a role of genetic alterations of selenoproteins in hepatocellular carcinoma risk.