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<p>Colorectal cancer (CRC) is the most common malignancy of the digestive system. Although research into the causes of CRC’s origin and progression has advanced over the past few decades, many details are still not fully understood. Circular RNAs (circRNAs), as a novel regulatory molecule, have been found to be closely involved in various key biological processes in CRC. CircRNAs also have been shown to encode proteins, which could offer new possibilities for therapeutic applications. This ability to produce tumor-specific proteins makes circRNA-based vaccines a potentially valuable approach for targeted cancer treatment. In this review, we summarize recent findings on the various roles of circRNAs in CRC and explore their potential in the development of protein-encoding circRNA vaccines for CRC therapy.</p>

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CircRNAs in Colorectal Cancer: Unveiling Their Roles and Exploring Therapeutic Potential

  • 期刊论文

  • 发表日期：

    2025年3月3日

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  • Yi-Han Ding,
  • Xiao-Hang Song,
  • Jing-Song Chen

摘要

Colorectal cancer (CRC) is the most common malignancy of the digestive system. Although research into the causes of CRC’s origin and progression has advanced over the past few decades, many details are still not fully understood. Circular RNAs (circRNAs), as a novel regulatory molecule, have been found to be closely involved in various key biological processes in CRC. CircRNAs also have been shown to encode proteins, which could offer new possibilities for therapeutic applications. This ability to produce tumor-specific proteins makes circRNA-based vaccines a potentially valuable approach for targeted cancer treatment. In this review, we summarize recent findings on the various roles of circRNAs in CRC and explore their potential in the development of protein-encoding circRNA vaccines for CRC therapy.