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<p>Data from simulation the responses of cardiomyocytes in a&#xa0;state of simulated fibrillation to a&#xa0;biphasic truncated exponential hyperpolarizing defibrillation pulse with energetically optimal first and second phase durations and duration of the pause between the phases were used to compare energy efficiencies for different values of the second-phase amplitude coefficient. The simulation results showed that increases in the relative energy of the hyperpolarizing pulse were associated with decreases in the defibrillation completeness index, while increases in the amplitude coefficient of the second phase of the pulse led to decreases in the relative energy at which onset of the decrease occurred. A&#xa0;further increase in the relative energy of the hyperpolarizing pulse led to a&#xa0;greater defibrillation completeness index over that of an identical depolarizing pulse.</p>

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Evaluation of the influence of the amplitude coefficient of the second phase of a biphasic truncated exponential hyperpolarizing defibrillation pulse on its energy efficiency

  • 期刊论文

  • 发表日期：

    2025年11月10日

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  • B. B. Gorbunov,
  • I. V. Nesterenko,
  • S. V. Selishchev

摘要

Data from simulation the responses of cardiomyocytes in a state of simulated fibrillation to a biphasic truncated exponential hyperpolarizing defibrillation pulse with energetically optimal first and second phase durations and duration of the pause between the phases were used to compare energy efficiencies for different values of the second-phase amplitude coefficient. The simulation results showed that increases in the relative energy of the hyperpolarizing pulse were associated with decreases in the defibrillation completeness index, while increases in the amplitude coefficient of the second phase of the pulse led to decreases in the relative energy at which onset of the decrease occurred. A further increase in the relative energy of the hyperpolarizing pulse led to a greater defibrillation completeness index over that of an identical depolarizing pulse.