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<p>Magnetic iron oxide Fe<sub>3</sub>O<sub>4</sub> nanoparticles were synthesized by laser ablation to obtain stabilized aqueous dispersions. Nanoparticle diameter varied over the range of 50–70 nm. A&#xa0;system based on electromagnets was used to position the nanoparticles in the central part of a&#xa0;joint in a&#xa0;laboratory animal in vivo, and this was demonstrated in three-dimensional X‑ray microtomography images. The resulting magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles can be used as agents for the mobilization, retention, and visualization of drugs in the treatment of osteoarthritis.</p>

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Synthesis, control and visualization of magnetic nanoparticles for tasks in theranostics

  • 期刊论文

  • 发表日期：

    2025年10月20日

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  • G. Yu. Galechyan,
  • A. S. Chernikov,
  • U. E. Kurilova,
  • A. Yu. Gerasimenko,
  • L. P. Ichkitidze,
  • D. A. Kochuev,
  • M. A. Dzus,
  • A. P. Orlov,
  • B. P. Ershov,
  • S. Yu. Tkachev,
  • K. S. Khor’kov

摘要

Magnetic iron oxide Fe3O4 nanoparticles were synthesized by laser ablation to obtain stabilized aqueous dispersions. Nanoparticle diameter varied over the range of 50–70 nm. A system based on electromagnets was used to position the nanoparticles in the central part of a joint in a laboratory animal in vivo, and this was demonstrated in three-dimensional X‑ray microtomography images. The resulting magnetic Fe3O4 nanoparticles can be used as agents for the mobilization, retention, and visualization of drugs in the treatment of osteoarthritis.