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<p>Current methods for the discovery, development, and application of drugs to combat brain diseases, including the most common and malignant cancer, glioblastoma, rely on traditional two-dimensional (2D) cell cultures, which have been shown to provide a&#xa0;poor reflection of natural physiology. Here we report the development of a&#xa0;novel three-dimensional (3D) dual-chamber chip for studying the effects of drugs on brain cells and slices; the chip consists of poly(dimethylsiloxane) and an optoelectronic device for wireless stimulation. The results show that this chip is able to operate with a&#xa0;minimal volume of fluid, to include multiple drugs simultaneously, and to test cell responses to drugs in parallel. The approach is easily reproducible, and this chip may become a&#xa0;powerful platform for solving problems such as high-throughput combination therapy with simultaneous application of drugs and stimulation.</p>

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A microfluidic chip with a wireless cell neuromodulation function

  • 期刊论文

  • 发表日期：

    2025年7月21日

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  • A. A. Galyastov,
  • E. A. Yusupovskaya,
  • N. R. Isaev,
  • A. G. Markov,
  • D. V. Telyshev

摘要

Current methods for the discovery, development, and application of drugs to combat brain diseases, including the most common and malignant cancer, glioblastoma, rely on traditional two-dimensional (2D) cell cultures, which have been shown to provide a poor reflection of natural physiology. Here we report the development of a novel three-dimensional (3D) dual-chamber chip for studying the effects of drugs on brain cells and slices; the chip consists of poly(dimethylsiloxane) and an optoelectronic device for wireless stimulation. The results show that this chip is able to operate with a minimal volume of fluid, to include multiple drugs simultaneously, and to test cell responses to drugs in parallel. The approach is easily reproducible, and this chip may become a powerful platform for solving problems such as high-throughput combination therapy with simultaneous application of drugs and stimulation.