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<p>Data from modeling of the responses of cardiomyocytes in a&#xa0;state of simulated fibrillation to a&#xa0;truncated exponential biphasic depolarizing defibrillation pulse with energetically optimal second phase duration, between-phase pause, and second-phase amplitude coefficient, were used to compare energy efficiencies for different first-phase durations. The modeling results showed that reducing the duration of the first phase of the pulse below the energetically optimal value of 4 msec led to a&#xa0;decrease in its energy efficiency over a&#xa0;wide range of relative energy values. Increasing the duration of the first phase above the optimal led to an increase in energy efficiency at low relative energy values.</p>

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Evaluation of the influence of the duration of the first phase of a truncated exponential biphasic depolarizing defibrillation pulse on its energy efficiency

  • 期刊论文

  • 发表日期：

    2025年3月4日

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  • B. B. Gorbunov,
  • I. V. Nesterenko,
  • S. V. Selishchev

摘要

Data from modeling of the responses of cardiomyocytes in a state of simulated fibrillation to a truncated exponential biphasic depolarizing defibrillation pulse with energetically optimal second phase duration, between-phase pause, and second-phase amplitude coefficient, were used to compare energy efficiencies for different first-phase durations. The modeling results showed that reducing the duration of the first phase of the pulse below the energetically optimal value of 4 msec led to a decrease in its energy efficiency over a wide range of relative energy values. Increasing the duration of the first phase above the optimal led to an increase in energy efficiency at low relative energy values.