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<p>The substantia nigra (SN) is located in the midbrain and consists of the pars compacta, which is the main source of dopamine in the striatum, and the pars reticularis, which is a&#xa0;key output zone of the basal ganglia. This structure plays an important role in the regulation of human neuropsychiatric processes, and individual differences in receptor levels are associated with unique personality traits. Parkinson’s disease (PD) is associated with a&#xa0;pathological process leading to the loss of neurons in the substantia nigra pars compacta, leading to dopamine deficiency and the onset of motor symptoms. The aims of the present work were to produce a&#xa0;3D visualization and to use scanning capillary microscopy to study the morphological features of substantia nigra tissue sections from a&#xa0;donor without neurological pathology and a&#xa0;patient with Parkinson’s disease.</p>

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Scanning capillary microscopy in studies of the substantia nigra of the human brain

  • 期刊论文

  • 发表日期：

    2025年1月14日

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  • A. I. Akhmetova,
  • T. O. Sovetnikov,
  • E. O. Zorikova,
  • G. S. Evtushenko,
  • Yu. L. Rybakov,
  • V. M. Gukasov,
  • I. V. Yaminskii

摘要

The substantia nigra (SN) is located in the midbrain and consists of the pars compacta, which is the main source of dopamine in the striatum, and the pars reticularis, which is a key output zone of the basal ganglia. This structure plays an important role in the regulation of human neuropsychiatric processes, and individual differences in receptor levels are associated with unique personality traits. Parkinson’s disease (PD) is associated with a pathological process leading to the loss of neurons in the substantia nigra pars compacta, leading to dopamine deficiency and the onset of motor symptoms. The aims of the present work were to produce a 3D visualization and to use scanning capillary microscopy to study the morphological features of substantia nigra tissue sections from a donor without neurological pathology and a patient with Parkinson’s disease.