Studies of the morphology and cytotoxicity of photosensitized metal chalcogenide nanoparticles

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发表日期：

2024年7月23日

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U. E. Kurilova,
A. S. Chernikov,
D. A. Kochuev,
L. S. Volkova,
A. A. Voznesenskaya,
R. V. Chkalov,
D. V. Abramov,
A. V. Kazak,
I. A. Suetina,
M. V. Mezentseva,
L. I. Russu,
A. Yu. Gerasimenko,
K. S. Khor’kov

摘要

Studies of the morphological features and influence of photosensitized WS₂, MoS₂, and ZnS nanoparticles synthesized by laser ablation and fragmentation in liquid on human fibroblast cells are presented. Microscopy data showed that all types of nanoparticles were spherical in shape, except for WS₂ nanoparticles, which were planar. Spherical nanoparticle sizes ranged from 20 to 90 nm, which meets the requirements for theranostics. Cytotoxicity studies demonstrated that MoS₂ nanoparticles had high biocompatibility, while other nanoparticle types slowed cell growth, indicating future potential for use in the treatment of various diseases in living organisms.