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<p>Aging is a complex process that includes chronological aging and cellular aging. Although chronological aging is irreversible, cellular aging, which is reversible, is closely associated with chronological aging. Understanding the complexity of the impact and mechanisms of aging on the male reproductive function is crucial in maintaining male fertility. This study reviews the effects and mechanisms associated with aging in males on male reproductive health. It also provides potential therapeutic strategies for alleviating the reproductive consequences of aging in males. Evidence from the literature revealed that aging suppresses testicular steroidogenesis and circulating testosterone, lowers spermatogenesis and sperm quality, and induces erectile dysfunction. These adverse events are mediated by mitochondrial dysfunction and reduced ATP production, oxidative stress, inflammation, apoptosis, and DNA damage. More so, telomere shortening, cellular senescence, and epigenetic modification play crucial roles. Modulation of these processes with antioxidants such as vitamin C, vitamin E, CoQ10, and zinc attenuates cellular aging and promotes male reproductive health.</p>

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The aging male: impact of aging on male reproduction

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • R. E. Akhigbe,
  • P. A. Oyedokun,
  • A. E. Adeogun,
  • O. O. Ogunleye,
  • C. A. Adegbola,
  • T. M. Akhigbe

摘要

Aging is a complex process that includes chronological aging and cellular aging. Although chronological aging is irreversible, cellular aging, which is reversible, is closely associated with chronological aging. Understanding the complexity of the impact and mechanisms of aging on the male reproductive function is crucial in maintaining male fertility. This study reviews the effects and mechanisms associated with aging in males on male reproductive health. It also provides potential therapeutic strategies for alleviating the reproductive consequences of aging in males. Evidence from the literature revealed that aging suppresses testicular steroidogenesis and circulating testosterone, lowers spermatogenesis and sperm quality, and induces erectile dysfunction. These adverse events are mediated by mitochondrial dysfunction and reduced ATP production, oxidative stress, inflammation, apoptosis, and DNA damage. More so, telomere shortening, cellular senescence, and epigenetic modification play crucial roles. Modulation of these processes with antioxidants such as vitamin C, vitamin E, CoQ10, and zinc attenuates cellular aging and promotes male reproductive health.