Scholarlink

<p>Emerging evidence has revealed a strong association between obstructive sleep apnea (OSA) and aging. Considering the critical role of the cardiovascular system, this review&#xa0;explores the key mechanisms linking OSA to cardiovascular aging through a focus on chronic intermittent hypoxia (CIH) -induced oxidative stress and chronic inflammation. Specifically, we examine six key pathways: (1) cellular senescence, (2) mitochondrial dysfunction, (3) metabolic dysregulation, (4) telomere attrition, (5) impaired intercellular communication, and (6) adipose tissue senescence.&#xa0;These insights provide a foundation for identifying novel interventions and therapeutic targets to mitigate or even reverse cardiovascular aging.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Obstructive sleep apnea and aging of the cardiovascular system: a multidimensional analysis of the mechanisms involved

  • 期刊论文

  • 发表日期：

    2025年10月21日

查看全文
  • Xiaolin Hao,
  • Yan Li,
  • Xiaoling Gao

摘要

Emerging evidence has revealed a strong association between obstructive sleep apnea (OSA) and aging. Considering the critical role of the cardiovascular system, this review explores the key mechanisms linking OSA to cardiovascular aging through a focus on chronic intermittent hypoxia (CIH) -induced oxidative stress and chronic inflammation. Specifically, we examine six key pathways: (1) cellular senescence, (2) mitochondrial dysfunction, (3) metabolic dysregulation, (4) telomere attrition, (5) impaired intercellular communication, and (6) adipose tissue senescence. These insights provide a foundation for identifying novel interventions and therapeutic targets to mitigate or even reverse cardiovascular aging.