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<p>Traditional Chinese Medicine (TCM), as a globally recognized phytomedicinal approach, has made significant contributions to healthcare and anti-aging research worldwide. Jingfang Granule (JFG), an established TCM preparation in China, was demonstrated to exert effects on prolonging lifespan and healthspan via the <i>Caenorhabditis elegans</i> model in this study. We employed RNA-seq analysis to investigate the complex genetic interactions through which JFG extends the lifespan of <i>C. elegans</i>. We observed that administering JFG to adult nematodes increased the transcription levels of extracellular matrix (ECM)-related genes (including collagen genes), reproduction-related genes (e.g., <i>egg-1</i>, <i>lin-41</i>), and stress-activated transcription factor-1 (<i>atfs-1</i>). JFG treatment slowed down the functional degradation of organs, such as the cuticle, reproductive system, and mitochondria, leading to enhanced innate immunity and fecundity. Our findings demonstrate that JFG protects nematodes from age-related physiological decline and extends both lifespan and healthspan. This study not only highlights the effects of JFG on delaying aging but also provides a deep understanding of the genetic interactions underlying its anti-aging benefits.</p>

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Jingfang granule extends lifespan and healthspan in Caenorhabditis elegans: insights from RNA-seq analysis of genetic mechanisms

  • 期刊论文

  • 发表日期：

    2025年8月23日

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  • Taili Zhao,
  • Yunhua Hou,
  • Chuanjiao Feng,
  • Rui Zhao,
  • Honghua Li,
  • Peipei Zhao,
  • Mengmeng Wang,
  • Jingli Ren,
  • Yiwei Meng,
  • Kuidong Xu,
  • Jia Liu,
  • Xin Yin,
  • Guimin Zhang,
  • Jingchun Yao,
  • Xuekui Xia

摘要

Traditional Chinese Medicine (TCM), as a globally recognized phytomedicinal approach, has made significant contributions to healthcare and anti-aging research worldwide. Jingfang Granule (JFG), an established TCM preparation in China, was demonstrated to exert effects on prolonging lifespan and healthspan via the Caenorhabditis elegans model in this study. We employed RNA-seq analysis to investigate the complex genetic interactions through which JFG extends the lifespan of C. elegans. We observed that administering JFG to adult nematodes increased the transcription levels of extracellular matrix (ECM)-related genes (including collagen genes), reproduction-related genes (e.g., egg-1, lin-41), and stress-activated transcription factor-1 (atfs-1). JFG treatment slowed down the functional degradation of organs, such as the cuticle, reproductive system, and mitochondria, leading to enhanced innate immunity and fecundity. Our findings demonstrate that JFG protects nematodes from age-related physiological decline and extends both lifespan and healthspan. This study not only highlights the effects of JFG on delaying aging but also provides a deep understanding of the genetic interactions underlying its anti-aging benefits.