<p>This study presents a comprehensive seismic fragility and loss assessment of a nine-story steel moment-resisting frame subjected to synthetic near-fault pulse-like ground motions. To overcome the limitations of amplitude scaling inherent in conventional incremental dynamic analysis, the cloud-stripe method is employed for fragility evaluation. In this approach, synthetic pulse-like ground motions are generated by combining a modified Mavroeidis-Papageorgiou wavelet method to simulate low-frequency pulses with a stochastic simulation to capture high-frequency components. Structural responses are assessed using key engineering demand parameters, including maximum inter-story drift, residual drift, and peak floor acceleration, while a story-based economic loss function quantifies post-earthquake repair costs. Results demonstrate that spectral velocity-based intensity measures more reliably characterize structural responses under tri-directional ground motions than conventional spectral acceleration-based measures. Furthermore, simplifying tri-directional motions to a bi-directional representation (e.g., one horizontal and one vertical component) significantly underestimates both damage probabilities and economic losses. These findings highlight the importance of incorporating tri-directional, pulse-like ground motion characteristics in performance-based earthquake engineering to achieve more accurate seismic risk assessments.</p>