<p>Numerical simulations and physical experiments stand out as the two most effective approaches for scrutinizing the seismic performance of single-layer cylindrical shell structures in large-span spaces. Given the substantial demands on labor and material resources entailed by experiments, numerical simulation has progressively emerged as the predominant method for probing the robust seismic response behavior of structures. In this study, ABAQUS was employed to construct finite element models for both the shaking table tests of shells, one without an infill wall and the other with an infill wall. The analysis encompassed self-oscillation characteristics and dynamic time courses. The findings indicated a commendable alignment between the numerical simulation results and the experimental outcomes. Furthermore, a judicious equivalent modeling method for the infill wall was introduced. The dynamic response analysis revealed that the seismic-induced damage to the infill wall significantly impacts the dynamic characteristics of the single-layer cylindrical shell, resulting in diminished structural ductility and ultimate bearing capacity.</p>