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<p>We evaluated immunogenicity of the experimental DNA-vaccine construct pVAX-prM-E encoding the polyprotein prM-E of the tick-borne encephalitis virus (strain Sofjin). It was shown that pVAX-prM-E administered to mice using a needle-free jet injector induced the production of high levels of virus-neutralizing antibodies. The level of humoral response to pVAX-prM-E was comparable to that induced by administration of the commercial Tick-E-Vac vaccine. ELISpot analysis of the T-cell response showed that the obtained construct induces high levels of IFNγ in response to stimulation with a pool of specific E protein peptides. These findings indicate the high protective potential of this experimental DNA vaccine.</p>

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DNA Vaccine Encoding the prM-E Polyprotein of the Tick-Borne Encephalitis Virus

  • 期刊论文

  • 发表日期：

    2026年7月29日

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  • E. V. Tigeeva,
  • V. A. Yakovlev,
  • M. B. Borgoyakova,
  • E. V. Starostina,
  • K. P. Makarova,
  • D. I. Vakhitov,
  • E. V. Protopopova,
  • V. A. Svyatchenko,
  • V. B. Loktev,
  • L. A. Kisakova,
  • D. N. Kisakov,
  • N. B. Rudometova,
  • A. P. Rudometov,
  • L. I. Karpenko

摘要

We evaluated immunogenicity of the experimental DNA-vaccine construct pVAX-prM-E encoding the polyprotein prM-E of the tick-borne encephalitis virus (strain Sofjin). It was shown that pVAX-prM-E administered to mice using a needle-free jet injector induced the production of high levels of virus-neutralizing antibodies. The level of humoral response to pVAX-prM-E was comparable to that induced by administration of the commercial Tick-E-Vac vaccine. ELISpot analysis of the T-cell response showed that the obtained construct induces high levels of IFNγ in response to stimulation with a pool of specific E protein peptides. These findings indicate the high protective potential of this experimental DNA vaccine.