Scholarlink

<p>During wound healing, which is accompanied by hypoxia at the initial stages, the gene expression profile in fibroblasts shifts to facilitate the synthesis of proteins necessary for tissue restoration. In this study, we describe the influence of various parameters, in particular oxygenation and CO<sub>2</sub> levels in the culture medium, on the implementation of fibroblast wound healing potential, assessed by the expression of HIF-1α-dependent and HIF-1α-independent genes. The presented cell hypoxic conditioning system demonstrates a possible approach to the treatment of chronic non-healing skin wounds based on the use of biocompatible and biodegradable scaffolds seeded with hypoxia-activated fibroblasts.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Expression of Genes Responsible for Wound Healing in Dermal Fibroblasts under Hypoxia

  • 期刊论文

  • 发表日期：

    2026年7月29日

查看全文
  • E. V. Solovieva,
  • K. A. Darienko,
  • A. A. Wainson,
  • A. A. Panteleyev

摘要

During wound healing, which is accompanied by hypoxia at the initial stages, the gene expression profile in fibroblasts shifts to facilitate the synthesis of proteins necessary for tissue restoration. In this study, we describe the influence of various parameters, in particular oxygenation and CO2 levels in the culture medium, on the implementation of fibroblast wound healing potential, assessed by the expression of HIF-1α-dependent and HIF-1α-independent genes. The presented cell hypoxic conditioning system demonstrates a possible approach to the treatment of chronic non-healing skin wounds based on the use of biocompatible and biodegradable scaffolds seeded with hypoxia-activated fibroblasts.