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<p>Inbred BALB/c mice were intragastrically administered with a new antitubercular compound macozinone (PBTZ169) or a combination of isoniazid, rifampicin, and pyrazinamide (HRZ) for six months; control animals received no antitubercular drugs. After 6 months, the microbiota of the large intestine was analyzed. Unlike HRZ combination, macozinone practically does not affect the microbiota: its composition remained the same as in the control group. In lung tissue, differences in the expression of some genes regulating the immune response were found. Two months post-infection with <i>Mycobacterium tuberculosis</i>, mice treated with either the HRZ combination or macozinone exhibited distinct immune responses to tuberculin.</p>

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Effect of Antitubercular Drug Macozinone (PBTZ169) on the Intestinal Microbiota and Immunity in Inbred Mice

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • B. V. Nikonenko,
  • I. V. Bocharova,
  • A. E. Donnikov,
  • S. I. Kajukova,
  • D. V. Dianov,
  • V. A. Makarov

摘要

Inbred BALB/c mice were intragastrically administered with a new antitubercular compound macozinone (PBTZ169) or a combination of isoniazid, rifampicin, and pyrazinamide (HRZ) for six months; control animals received no antitubercular drugs. After 6 months, the microbiota of the large intestine was analyzed. Unlike HRZ combination, macozinone practically does not affect the microbiota: its composition remained the same as in the control group. In lung tissue, differences in the expression of some genes regulating the immune response were found. Two months post-infection with Mycobacterium tuberculosis, mice treated with either the HRZ combination or macozinone exhibited distinct immune responses to tuberculin.