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<p>The antidepressant properties of DAB-21 a compound with anxiolytic activity, were studied in C57BL/6 mice after modeling chronic unpredictable mild stress. In the Porsolt swim and tail suspension tests, the effect of DAB-21 was similar to that of amitriptyline, imipramine, and fluoxetine. In the open field test, the substance did not stimulate the motor activity of animals, which excludes the pseudo-antidepressant effect. HPLC analysis of monoamines and their metabolites in the frontal cortex showed that the 5-HIAA/serotonin ratio in animals treated with DAB-21 was 0.1, which is closest to that in the fluoxetine group. These findings suggest that the anxiolytic and antidepressant effects of DAB-21 are mediated via the serotonergic pathway.</p>

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Antidepressant Activity of 11-Dialkylaminoethyl-2,3,4,5-tetrahydrodiazepino[1,2-a]benzimidazole Derivative DAB-21 in a Model of Chronic Unpredictable Mild Stress

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • M. O. Maltseva,
  • D. V. Maltsev,
  • M. V. Miroshnikov,
  • L. A. Smirnova,
  • L. N. Divaeva,
  • A. S. Morkovnik,
  • A. A. Spasov

摘要

The antidepressant properties of DAB-21 a compound with anxiolytic activity, were studied in C57BL/6 mice after modeling chronic unpredictable mild stress. In the Porsolt swim and tail suspension tests, the effect of DAB-21 was similar to that of amitriptyline, imipramine, and fluoxetine. In the open field test, the substance did not stimulate the motor activity of animals, which excludes the pseudo-antidepressant effect. HPLC analysis of monoamines and their metabolites in the frontal cortex showed that the 5-HIAA/serotonin ratio in animals treated with DAB-21 was 0.1, which is closest to that in the fluoxetine group. These findings suggest that the anxiolytic and antidepressant effects of DAB-21 are mediated via the serotonergic pathway.