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<p>We studied the effect of α<sub>2</sub>-adrenoreceptor stimulation on functional parameters of Langendorff-isolated heart from pubertal rats subjected to restriction of motor activity during the early postnatal ontogeny. Clonidine hydrochloride, an agonist of α<sub>2</sub>-adrenoreceptors, was used at concentrations of 10<sup>–9</sup>-10<sup>–6</sup> M. After restriction of motor activity, stimulation of α<sub>2</sub>-adrenoreceptors with clonidine at the studied concentrations had a positive inotropic effect. α<sub>2</sub>-Adrenoreceptor stimulation led to a dose-dependent decrease in coronary flow, and this effect was more pronounced after hypokinesia. The role of α<sub>2</sub>-adrenoreceptors in the cardiovascular system under conditions of motor restriction requires further study considering age-related features.</p>

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Effect of α2-Adrenergic Receptor Stimulation on Isolated Rat Heart during Puberty after Hypokinesia

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • M. I. Sungatullina,
  • R. I. Zaripova,
  • A. M. Sadykov,
  • A. L. Zefirov,
  • N. I. Ziyatdinova,
  • T. L. Zefirov

摘要

We studied the effect of α2-adrenoreceptor stimulation on functional parameters of Langendorff-isolated heart from pubertal rats subjected to restriction of motor activity during the early postnatal ontogeny. Clonidine hydrochloride, an agonist of α2-adrenoreceptors, was used at concentrations of 10–9-10–6 M. After restriction of motor activity, stimulation of α2-adrenoreceptors with clonidine at the studied concentrations had a positive inotropic effect. α2-Adrenoreceptor stimulation led to a dose-dependent decrease in coronary flow, and this effect was more pronounced after hypokinesia. The role of α2-adrenoreceptors in the cardiovascular system under conditions of motor restriction requires further study considering age-related features.