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<p>We evaluated the association of alleles of human leukocyte antigen (HLA) class II genes and the levels of secretion of IL-4 and IFNγ in the blood of individuals vaccinated/revaccinated with a live plague vaccine and living in the Gorno-Altai high-mountain and Tuvinian mountain natural plague foci. Significant differences were identified in the blood content of IL-4 and IFNγ in volunteers with different variants of alleles in the <i>HLA-DRB1</i>, <i>HLA-DQA1</i>, and <i>HLA-DQB1</i> loci, which indicates a substantial influence of their polymorphism on the immunological reactivity during specific plague prevention. Further research within the framework of immunological monitoring of the population living in plague-endemic territories will allow identifying the features of the influence of polymorphism of HLA class II genes on the formation of post-vaccination anti-plague immunity in humans.</p>

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The Role of Polymorphism of HLA Class II Genes in Postvaccination Plague Immunity

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • K. M. Korytov,
  • V. I. Dubrovina,
  • A. B. Pyatyidesyatnikova,
  • D. D. Bryukhova,
  • N. O. Kiseleva,
  • E. A. Kuzina,
  • S. V. Balakhonov

摘要

We evaluated the association of alleles of human leukocyte antigen (HLA) class II genes and the levels of secretion of IL-4 and IFNγ in the blood of individuals vaccinated/revaccinated with a live plague vaccine and living in the Gorno-Altai high-mountain and Tuvinian mountain natural plague foci. Significant differences were identified in the blood content of IL-4 and IFNγ in volunteers with different variants of alleles in the HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci, which indicates a substantial influence of their polymorphism on the immunological reactivity during specific plague prevention. Further research within the framework of immunological monitoring of the population living in plague-endemic territories will allow identifying the features of the influence of polymorphism of HLA class II genes on the formation of post-vaccination anti-plague immunity in humans.