Scholarlink

<p>We studied <i>ex vivo</i> effect of α2A/D-adrenoreceptor (α2A/D-AR) antagonist RX821002 at concentrations of 10<sup>–9</sup>-10<sup>–6</sup> M on inotropy, chronotropy, and coronary flow in Langendorff-isolated rat heart. The minimum concentration of the antagonist did not affect the studied cardiac parameters. The α2A/D-AR antagonist at the concentrations of 10<sup>–8</sup>-10<sup>–6</sup> M increased contraction pressure of the left ventricular myocardium and coronary flow. RX821002 exerted a positive and negative chronotropic effect depending on the concentration. Application of RX821002 at a concentration of 10<sup>–7</sup> M caused dual-effect: both an increase and a decrease in heart rate were observed. The most pronounced changes in chronotropy and inotropy were revealed after application of α2A/D-AR blocker at a concentration of 10<sup>–7</sup> M.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Peculiarities of the Effect of Selective of α2A/D-Adrenoreceptor Blockade on the Isolated Rat Heart

  • 期刊论文

  • 发表日期：

    2026年2月1日

查看全文
  • L. I. Khisamieva,
  • A. M. Sadykov,
  • A. L. Zefirov,
  • N. I. Ziyatdinova,
  • T. L. Zefirov

摘要

We studied ex vivo effect of α2A/D-adrenoreceptor (α2A/D-AR) antagonist RX821002 at concentrations of 10–9-10–6 M on inotropy, chronotropy, and coronary flow in Langendorff-isolated rat heart. The minimum concentration of the antagonist did not affect the studied cardiac parameters. The α2A/D-AR antagonist at the concentrations of 10–8-10–6 M increased contraction pressure of the left ventricular myocardium and coronary flow. RX821002 exerted a positive and negative chronotropic effect depending on the concentration. Application of RX821002 at a concentration of 10–7 M caused dual-effect: both an increase and a decrease in heart rate were observed. The most pronounced changes in chronotropy and inotropy were revealed after application of α2A/D-AR blocker at a concentration of 10–7 M.