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<p>We studied the effect of 14.5 MeV neutron dose ultrafractionation on survival and recovery kinetics from radiation damage in normal V-79 and tumor B14-150 cells. Neutron doses of 0.5, 2, 4, and 6 Gy were split into 1, 2, 3, and 4 fractions. The observed recovery times 1.6 h (V-79) and 0.94 h (B14-150) indicate the possibility of reducing radiation damage with increasing the number of fractions. It was shown that neutron irradiation efficacy decreases when intervals between fractions exceed 1 h.</p>

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Efficacy of Single and Fractionated Neutron Irradiation of Normal and Tumor Cells In Vitro

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • E. V. Koryakina,
  • A. A. Pichkunova,
  • M. V. Troshina,
  • V. I. Potetnya,
  • V. O. Saburov,
  • E. V. Litun,
  • A. A. Lychagin,
  • S. N. Koryakin,
  • S. A. Ivanov,
  • A. D. Kaprin

摘要

We studied the effect of 14.5 MeV neutron dose ultrafractionation on survival and recovery kinetics from radiation damage in normal V-79 and tumor B14-150 cells. Neutron doses of 0.5, 2, 4, and 6 Gy were split into 1, 2, 3, and 4 fractions. The observed recovery times 1.6 h (V-79) and 0.94 h (B14-150) indicate the possibility of reducing radiation damage with increasing the number of fractions. It was shown that neutron irradiation efficacy decreases when intervals between fractions exceed 1 h.