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<p>In a longitudinal study of permanent Arctic residents, an actigraphic analysis of sleep quality indicators across different seasons revealed no significant overall seasonal differences in sleep efficiency (<i>p</i> = 0.487). However, <i>TT</i> homozygotes for the <i>CLOCK</i> gene <i>rs1801260</i> polymorphism the exhibited lower sleep efficiency, particularly in spring and summer. Multiple linear regression, incorporating categorical covariates including <i>rs1801260</i> polymorphism, sex, season, indigenous status, age, and body mass index, identified the <i>TT</i> genotype as the sole significant predictor of sleep efficiency (β = -0.215; <i>p</i> = 0.029), confirming its association with poorer sleep quality.</p>

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Association of CLOCK rs1801260 Polymorphism with Sleep Quality in Residents of the Far North

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • D. G. Gubin,
  • S. N. Kolomeychuk,
  • M. F. Borisenkov,
  • I. M. Petrov,
  • A. A. Markov,
  • Yu. A. Petrova,
  • K. A. Voronin,
  • M. S. Mezhakova,
  • Yu. V. Boldyreva,
  • V. A. Markov,
  • A. U. Shigabaeva

摘要

In a longitudinal study of permanent Arctic residents, an actigraphic analysis of sleep quality indicators across different seasons revealed no significant overall seasonal differences in sleep efficiency (p = 0.487). However, TT homozygotes for the CLOCK gene rs1801260 polymorphism the exhibited lower sleep efficiency, particularly in spring and summer. Multiple linear regression, incorporating categorical covariates including rs1801260 polymorphism, sex, season, indigenous status, age, and body mass index, identified the TT genotype as the sole significant predictor of sleep efficiency (β = -0.215; p = 0.029), confirming its association with poorer sleep quality.