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<p>Global ischemia (45 min) followed by reperfusion (30 min) was modeled in isolated hearts from male Wistar rats. A selective μ2-opioid receptor agonist endomorphin-1 (152 nmol/liter) was added to the perfusate at the onset of reperfusion. Myocardial levels of inositol triphosphate and diacylglycerol were measured. It was found that endomorphin-1 improved cardiac contractility parameters during reperfusion. Furthermore, perfusion with a solution containing endomorphin-1 increased myocardial inositol triphosphate and diacylglycerol concentrations by 4.1 and 6 times, respectively. Hence, stimulation of cardiac μ2-opioid receptors increases cardiac tolerance to reperfusion injury.</p>

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Cardioprotective Effect of Endomorphin-1 In Vitro: the Role of Intracellular Messengers

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • B. K. Kurbatov,
  • A. S. Gorbunov,
  • A. V. Mukhomedzyanov,
  • S. V. Popov,
  • N. V. Naryzhnaya,
  • M. Kilin,
  • L. N. Maslov

摘要

Global ischemia (45 min) followed by reperfusion (30 min) was modeled in isolated hearts from male Wistar rats. A selective μ2-opioid receptor agonist endomorphin-1 (152 nmol/liter) was added to the perfusate at the onset of reperfusion. Myocardial levels of inositol triphosphate and diacylglycerol were measured. It was found that endomorphin-1 improved cardiac contractility parameters during reperfusion. Furthermore, perfusion with a solution containing endomorphin-1 increased myocardial inositol triphosphate and diacylglycerol concentrations by 4.1 and 6 times, respectively. Hence, stimulation of cardiac μ2-opioid receptors increases cardiac tolerance to reperfusion injury.