Scholarlink

<p>The effects of alkylated phenol antioxidants, dibornol (2,6-diisobornyl-4-methylphenol) and prostagenin (4-hydroxymethyl-2,6-diisobornylphenol), on the level of DNA damage, free radical light sum, antioxidant capacity, and the redox balance of testicular cells were studied in 12-week-old male Wistar rats. Using the alkaline comet assay (single-cell gel electrophoresis), we demonstrated that the substituted phenols effectively reduce DNA damage in rat testicular cells, exhibiting comparable genoprotective efficacy. Chemiluminescence analysis demonstrated that testicular tissue cells were sensitive to the antioxidant effects of both compounds. However, based on the antioxidant defense and redox parameters, prostagenin exhibited superior activity. Specifically, prostagenin administration shifted the cellular redox balance toward a more reduced state.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparative Evaluation of the Protective Activity of Dibornol and Prostagenin in a Model of DNA Damage in Rat Testicular Tissue Cells

  • 期刊论文

  • 发表日期：

    2026年1月1日

查看全文
  • T. G. Borovskaya,
  • Yu. A. Shchemerova,
  • A. V. Zaiko,
  • E. G. Korneeva,
  • E. V. Buravlev,
  • I. Yu. Chukicheva,
  • A. V. Kuchin,
  • M. Yu. Minakova,
  • V. E. Goldberg

摘要

The effects of alkylated phenol antioxidants, dibornol (2,6-diisobornyl-4-methylphenol) and prostagenin (4-hydroxymethyl-2,6-diisobornylphenol), on the level of DNA damage, free radical light sum, antioxidant capacity, and the redox balance of testicular cells were studied in 12-week-old male Wistar rats. Using the alkaline comet assay (single-cell gel electrophoresis), we demonstrated that the substituted phenols effectively reduce DNA damage in rat testicular cells, exhibiting comparable genoprotective efficacy. Chemiluminescence analysis demonstrated that testicular tissue cells were sensitive to the antioxidant effects of both compounds. However, based on the antioxidant defense and redox parameters, prostagenin exhibited superior activity. Specifically, prostagenin administration shifted the cellular redox balance toward a more reduced state.