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<p>In the streptozotocin–nicotinamide model of type 2 diabetes mellitus (T2DM), erythrocytes exhibit increased resistance to osmotic and colloid-osmotic lysis. For thymocytes, cell volume regulation in T2DM was found to be significantly less effective than in the control. Using the Langendorff isolated heart retrograde perfusion model, we demonstrated that reperfusion after 30-min global ischemia leads to a dramatic decrease in HR, a decrease in left-ventricular systolic pressure, left-ventricular developed pressure, and the rate of left-ventricular pressure rise and fall. While the general pattern of heart dynamics during ischemia/reperfusion was preserved in T2DM, post-reperfusion HR was significantly lower than in the control.</p>

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Erythrocyte Integrity, Thymocyte Volume Regulation, and Functional State of the Heart during Ischemia/Reperfusion in Rats with Type 2 Diabetes Mellitus

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • O. J. Khamidova,
  • N. D. Oljaev,
  • D. D. Fayziev,
  • P. G. Merzlyak,
  • R. Sh. Kurbannazarova,
  • M. Z. Maksudov,
  • R. Z. Sabirov,
  • I. F. Abdullaev

摘要

In the streptozotocin–nicotinamide model of type 2 diabetes mellitus (T2DM), erythrocytes exhibit increased resistance to osmotic and colloid-osmotic lysis. For thymocytes, cell volume regulation in T2DM was found to be significantly less effective than in the control. Using the Langendorff isolated heart retrograde perfusion model, we demonstrated that reperfusion after 30-min global ischemia leads to a dramatic decrease in HR, a decrease in left-ventricular systolic pressure, left-ventricular developed pressure, and the rate of left-ventricular pressure rise and fall. While the general pattern of heart dynamics during ischemia/reperfusion was preserved in T2DM, post-reperfusion HR was significantly lower than in the control.