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<p>The paper describes the effect of a plant extract composition on the metabolism of extracellular matrix (ECM) components in the liver of rats fed a high-fat diet. High-fat diet for 4 weeks increased the content of sulfated glycosaminoglycans, and activation of collagen metabolism and suppression of hyaluronidase activity were detected after 7 weeks. These changes created favorable conditions for fibrogenesis stimulation. The balance between MMP9 and TIMP-1 activities was preserved, but neither severe nor moderate changes in liver ECM were noted at the structural level. Phytocomposition administered against the background of the high-fat diet alleviated pathological remodeling of ECM, which may represent a key mechanism of its action.</p>

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Effects of a High-Fat Diet and a Plant Extract Composition on Extracellular Matrix Remodeling in Rat Liver

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • O. P. Molodykh,
  • L. B. Kim,
  • I. Yu. Deulin,
  • A. M. Sinyavskaya,
  • A. N. Putyatina,
  • N. A. Palchikova,
  • V. G. Selyatitskaya,
  • M. I. Voevoda

摘要

The paper describes the effect of a plant extract composition on the metabolism of extracellular matrix (ECM) components in the liver of rats fed a high-fat diet. High-fat diet for 4 weeks increased the content of sulfated glycosaminoglycans, and activation of collagen metabolism and suppression of hyaluronidase activity were detected after 7 weeks. These changes created favorable conditions for fibrogenesis stimulation. The balance between MMP9 and TIMP-1 activities was preserved, but neither severe nor moderate changes in liver ECM were noted at the structural level. Phytocomposition administered against the background of the high-fat diet alleviated pathological remodeling of ECM, which may represent a key mechanism of its action.