Scholarlink

<p>In this study, we evaluated the level of proinflammatory cytokine IL-1β in left-ventricular myocardium of rats with arterial hypertension at different periods, insulin-dependent diabetes mellitus, and a combination of these conditions. We found that IL-1β expression in the left ventricle was significantly increased in isolated diabetes mellitus, 57-week arterial hypertension, and combination of 38-week arterial hypertension and diabetes mellitus. In the group with 38-week arterial hypertension, IL-1β expression also exceeded the control level (normotensive rats), but the shifts were less pronounced. Increased IL-1β production in the myocardium can be considered a mechanism triggering inflammatory programmed death (pyroptosis) of cardiomyocytes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Expression of IL-1β in the Left-Ventricular Myocardium of Rats with Insulin-Dependent Diabetes Mellitus and Its Combination with Arterial Hypertension

  • 期刊论文

  • 发表日期：

    2026年1月1日

查看全文
  • A. P. Sklifasovskaya,
  • M. L. Blagonravov,
  • V. A. Goryachev,
  • M. M. Azova

摘要

In this study, we evaluated the level of proinflammatory cytokine IL-1β in left-ventricular myocardium of rats with arterial hypertension at different periods, insulin-dependent diabetes mellitus, and a combination of these conditions. We found that IL-1β expression in the left ventricle was significantly increased in isolated diabetes mellitus, 57-week arterial hypertension, and combination of 38-week arterial hypertension and diabetes mellitus. In the group with 38-week arterial hypertension, IL-1β expression also exceeded the control level (normotensive rats), but the shifts were less pronounced. Increased IL-1β production in the myocardium can be considered a mechanism triggering inflammatory programmed death (pyroptosis) of cardiomyocytes.