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<p>Neutrophil extracellular traps (NETs) are considered as a potential mechanism contributing to inflammation in pregnancy complications. To date, no “gold standard” for NET quantification has been established. The content of NETs varies depending on the detection method. The level of NETs and their components in pregnant women with preeclampsia was assessed using cytological and immunofluorescence methods, ELISA, and flow cytometry. All applied methods showed significantly elevated levels of both NETs and their individual components in women with preeclampsia.</p>

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Approaches to Identifying Neutrophil Extracellular Traps and Their Components in Preeclampsia

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • I. I. Stepanova,
  • I. V. Byadovskaya,
  • E. N. Plakhotina,
  • T. N. Belousova,
  • A. P. Aleksankin,
  • A. A. Akhmetshina,
  • V. I. Klaushuk,
  • K. A. Artemeva,
  • N. V. Nizyaeva,
  • Yu. E. Dobrokhotova

摘要

Neutrophil extracellular traps (NETs) are considered as a potential mechanism contributing to inflammation in pregnancy complications. To date, no “gold standard” for NET quantification has been established. The content of NETs varies depending on the detection method. The level of NETs and their components in pregnant women with preeclampsia was assessed using cytological and immunofluorescence methods, ELISA, and flow cytometry. All applied methods showed significantly elevated levels of both NETs and their individual components in women with preeclampsia.