<p>We studied the role of microRNA-802 (miR-802) in regulating the sensitivity of non-small cell lung cancer and colorectal cancer cells to the cytotoxic activity of macrophages. Previously, we demonstrated that cells resistant to macrophage-mediated effects are characterized by reduced miR-802 expression. In this study, tumor cell lines expressing miR-802 were generated, and their resistance to macrophages and proliferative activity were assessed. It was found that miR-802 expression decreases cell resistance to macrophage cytotoxicity and slows their proliferation, suggesting its potential role as a tumor suppressor. However, in cells already exhibiting a resistant phenotype, miR-802 expression is suppressed, likely through activation of epigenetic or post-transcriptional mechanisms. These results are consistent with previously published data on the dual role of miR-802 in different tumor types. Thus, miR-802 may play an important role in the development of tumor cell resistance to the immune response and could be of interest as a potential therapeutic target in immunotherapeutic approaches.</p>