Scholarlink

<p>The major antigens of the influenza virus are the surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). Antibodies to HA are virus-neutralizing, whereas NA-specific antibodies alleviate the severity of the infection while also conferring protective immunity. In cases of genetic drift or antigenic shift among circulating influenza strains, anti-HA antibodies may show reduced cross-neutralization efficiency. Therefore, when assessing susceptibility to influenza following infection or vaccination, it is crucial to consider immune responses directed against the second principal antigenic component, NA. NA-specific antibodies have been demonstrated to possess cross-reactive and protective properties. We obtained a recombinant NA protein of influenza A virus and used it for the detection of virus-specific IgG to influenza A viruses.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Production of Recombinant Neuraminidase NA Protein of Influenza A/H5N2 Virus and Its Application for the Detection of Virus-Specific IgG to Influenza A Viruses

  • 期刊论文

  • 发表日期：

    2025年12月1日

查看全文
  • T. V. Gupalova,
  • E. A. Bormotova,
  • G. F. Leontieva,
  • T. A. Kramskaya,
  • Yu. A. Desheva,
  • A. N. Suvorov

摘要

The major antigens of the influenza virus are the surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). Antibodies to HA are virus-neutralizing, whereas NA-specific antibodies alleviate the severity of the infection while also conferring protective immunity. In cases of genetic drift or antigenic shift among circulating influenza strains, anti-HA antibodies may show reduced cross-neutralization efficiency. Therefore, when assessing susceptibility to influenza following infection or vaccination, it is crucial to consider immune responses directed against the second principal antigenic component, NA. NA-specific antibodies have been demonstrated to possess cross-reactive and protective properties. We obtained a recombinant NA protein of influenza A virus and used it for the detection of virus-specific IgG to influenza A viruses.