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<p>Antibacterial properties of experimental titanium alloy implant samples (disks with a diameter of 10.0 ± 1 mm and thickness 1.0 mm) with a calcium-phosphate coating including an antibacterial component (vancomycin and cefazolin) against gram-positive pathogens (<i>Staphylococcus aureus</i>, <i>S. epidermidis</i>, <i>Enterococcus faecalis</i>) were studied <i>in vitro</i> using the disk diffusion method. The tested antibiotic concentrations were 2.5, 5.0, and 7.5 wt% in dry matter. Implants with vancomycin at all three concentrations exhibited a pronounced antibacterial effect against reference strains of <i>S. aureus</i>, <i>S. epidermidis</i>, and <i>E. faecalis</i>. Implants with cefazolin were effective only against <i>S. aureus</i>.</p>

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Evaluation of Experimental Titanium Alloy Implants with Calcium Phosphate Coating and Antibacterial Components against Gram-Positive Pathogens: An Experimental Study

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • A. V. Popkov,
  • N. A. Kononovich,
  • I. V. Shipitsyna,
  • A. L. Shastov,
  • D. A. Popkov,
  • S. I. Tverdokhlebov,
  • A. I. Kozelskaya,
  • S. I. Goreninskii,
  • K. N. Verzunova

摘要

Antibacterial properties of experimental titanium alloy implant samples (disks with a diameter of 10.0 ± 1 mm and thickness 1.0 mm) with a calcium-phosphate coating including an antibacterial component (vancomycin and cefazolin) against gram-positive pathogens (Staphylococcus aureus, S. epidermidis, Enterococcus faecalis) were studied in vitro using the disk diffusion method. The tested antibiotic concentrations were 2.5, 5.0, and 7.5 wt% in dry matter. Implants with vancomycin at all three concentrations exhibited a pronounced antibacterial effect against reference strains of S. aureus, S. epidermidis, and E. faecalis. Implants with cefazolin were effective only against S. aureus.