Scholarlink

<p>A murine model of endometriosis was employed to evaluate the pharmacological efficacy of therapeutic compounds. Endometriosis was modeled by autotransplantation of uterine horn fragments onto the intestinal mesentery in three experimental paradigms: 1) with subcutaneous administration of estradiol; 2) a short-term protocol without estradiol; 3) a prolonged protocol without estradiol and with delayed administration of the test compound. In all animals, well-demarcated, rounded endometriotic lesions (endometriomas) were consistently observed at the implantation sites. Endoferin demonstrated its highest efficacy under the short-term, hormone-free protocol. The administration of exogenous estradiol interfered with the manifestation of the pharmacological activity of the test drug. Thus, a rapid <i>in vivo</i> method for assessing the therapeutic efficacy of candidate drugs was developed.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Modeling Endometriosis in Mice and Pharmacological Activity of the Drug Endoferin

  • 期刊论文

  • 发表日期：

    2025年12月1日

查看全文
  • A. V. Ilyichev,
  • M. V. Belopolskaya,
  • V. V. Pavshintsev,
  • D. A. Areshidze,
  • A. A. Bustios-Guryanova,
  • M. L. Lovat,
  • L. M. Mikhaleva

摘要

A murine model of endometriosis was employed to evaluate the pharmacological efficacy of therapeutic compounds. Endometriosis was modeled by autotransplantation of uterine horn fragments onto the intestinal mesentery in three experimental paradigms: 1) with subcutaneous administration of estradiol; 2) a short-term protocol without estradiol; 3) a prolonged protocol without estradiol and with delayed administration of the test compound. In all animals, well-demarcated, rounded endometriotic lesions (endometriomas) were consistently observed at the implantation sites. Endoferin demonstrated its highest efficacy under the short-term, hormone-free protocol. The administration of exogenous estradiol interfered with the manifestation of the pharmacological activity of the test drug. Thus, a rapid in vivo method for assessing the therapeutic efficacy of candidate drugs was developed.