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<p>Although statins are among the most frequently prescribed drugs worldwide, their effect on the electrical activity of the heart, especially under chronic exposure, is poorly studied. We analyzed changes in the main repolarizing potassium currents in ventricular cardiomyocytes isolated from mice under chronic atorvastatin exposure. The mice received atorvastatin in drinking water at a dose of 10 mg/kg for 1 month. The whole-cell patch-clamp measurements showed an increase in the ultrarapid delayed rectifier potassium current <i>I</i><sub>Kur</sub> in the experimental group of mice (by ~40% in comparison with the control), with no changes in the transient outward potassium current <i>I</i><sub>to</sub> and the inward rectifier potassium current <i>I</i><sub>K1</sub>. No differences in the action potential configuration were revealed, which suggests possible changes in depolarizing currents under the influence of atorvastatin.</p>

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Changes in Repolarizing Currents in Mouse Cardiomyocytes Following Chronic Atorvastatin Exposure

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • I. Dzhumaniiazova,
  • T. S. Filatova,
  • G. F. Zakyrjanova,
  • A. V. Shamshura,
  • O. B. Pustovit,
  • D. V. Abramochkin

摘要

Although statins are among the most frequently prescribed drugs worldwide, their effect on the electrical activity of the heart, especially under chronic exposure, is poorly studied. We analyzed changes in the main repolarizing potassium currents in ventricular cardiomyocytes isolated from mice under chronic atorvastatin exposure. The mice received atorvastatin in drinking water at a dose of 10 mg/kg for 1 month. The whole-cell patch-clamp measurements showed an increase in the ultrarapid delayed rectifier potassium current IKur in the experimental group of mice (by ~40% in comparison with the control), with no changes in the transient outward potassium current Ito and the inward rectifier potassium current IK1. No differences in the action potential configuration were revealed, which suggests possible changes in depolarizing currents under the influence of atorvastatin.