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<p>The serum levels of oxidative stress marker, ischemia-modified albumin (IMA) were studied in healthy young (18-49 years), middle-aged (51-68 years), elderly and older (73-99 years) people. The content of IMA was measured using albumin cobalt binding assay. In addition, the IMA/albumin ratio (IMAR) was calculated. The content of IMA was elevated in the elderly individuals in comparison with the other two age groups (<i>p</i> &lt; 0.05). Similar changes were observed for IMAR (<i>p</i> &lt; 0.01). A positive correlation was established between the levels of IMA, IMAR, and age in the total group of volunteers (<i>r</i> = 0.308, <i>p</i> &lt; 0.05 and <i>r</i> = 0.412, <i>p</i> &lt; 0.01, respectively). The results show that oxidative modification of serum albumin increases with age.</p>

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The Level of Ischemia-Modified Albumin in Healthy Individuals of Different Age Groups

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Yu. O. Teselkin,
  • I. V. Babenkova,
  • I. V. Tarasova,
  • A. A. Kubrikova,
  • I. D. Strazhesko,
  • O. N. Tkacheva,
  • A. N. Osipov

摘要

The serum levels of oxidative stress marker, ischemia-modified albumin (IMA) were studied in healthy young (18-49 years), middle-aged (51-68 years), elderly and older (73-99 years) people. The content of IMA was measured using albumin cobalt binding assay. In addition, the IMA/albumin ratio (IMAR) was calculated. The content of IMA was elevated in the elderly individuals in comparison with the other two age groups (p < 0.05). Similar changes were observed for IMAR (p < 0.01). A positive correlation was established between the levels of IMA, IMAR, and age in the total group of volunteers (r = 0.308, p < 0.05 and r = 0.412, p < 0.01, respectively). The results show that oxidative modification of serum albumin increases with age.