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<p>Using <i>in vivo</i> microscopy, changes in the diameter of pial arterial microvessels were studied in rats with modeled moderate acute blood loss followed by whole-body cooling against the background of a single administration of tranexamic acid at a dose of 10 mg/kg. The antifibrinolytic agent enhanced vasoconstrictor responses of the arterioles during deep cooling, but had no significant effect at the stages of mild and moderate hypothermia.</p>

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Effect of Tranexamic Acid Administration on the State of Pial Arterial Vessels in Rats with Acute Hemorrahage and Hypothermia

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • N. N. Melnikova

摘要

Using in vivo microscopy, changes in the diameter of pial arterial microvessels were studied in rats with modeled moderate acute blood loss followed by whole-body cooling against the background of a single administration of tranexamic acid at a dose of 10 mg/kg. The antifibrinolytic agent enhanced vasoconstrictor responses of the arterioles during deep cooling, but had no significant effect at the stages of mild and moderate hypothermia.