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<p>Hypothermia is accompanied by the development of a number of pathological processes, many of these are associated with mitochondrial dysfunction. Plant polyphenols, in particular, dihydroquercetin, can act as therapeutic agents with a mitoprotective effect. We studied the effects of dihydroquercetin on the respiratory parameters of rat liver mitochondria under conditions of moderate hypothermia. A 5-day course of dihydroquercetin (100 mg/kg) had a significant protective effect on the bioenergetics of the liver mitochondria in hypothermic rats, which was seen from a decrease in mitochondrial proton leakage and increased affinity of the respiratory chain to ADP and oxidation–phosphorylation coupling.</p>

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Effects of the Dihydroquercetin on Respiratory Parameters of Liver Mitochondria in Rats under Conditions of Hypothermia

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • R. A. Khalilov,
  • A. M. Dzhafarova,
  • V. R. Abdullayev,
  • Z. G. Rabadanova

摘要

Hypothermia is accompanied by the development of a number of pathological processes, many of these are associated with mitochondrial dysfunction. Plant polyphenols, in particular, dihydroquercetin, can act as therapeutic agents with a mitoprotective effect. We studied the effects of dihydroquercetin on the respiratory parameters of rat liver mitochondria under conditions of moderate hypothermia. A 5-day course of dihydroquercetin (100 mg/kg) had a significant protective effect on the bioenergetics of the liver mitochondria in hypothermic rats, which was seen from a decrease in mitochondrial proton leakage and increased affinity of the respiratory chain to ADP and oxidation–phosphorylation coupling.