Scholarlink

<p>We studied cardiac relaxation disorders on a rat model of DOX-induced cardiomyopathy (DOX, 2 mg/kg/week for 2 weeks). Left ventricular pressure and volume were synchronously recorded <i>in vivo</i> at baseline and under increased doses of dobutamine (DBA, 1-32 μg/kg/min). Left ventricular diastolic stiffness constants were calculated; the dose dependence of HR and isovolumic relaxation time (tau) was evaluated. In rats with cardiomyopathy, the diastolic stiffness constants increased with increasing the DBA doses, which was absent in the control; HR and tau showed opposite changes. The mean angular coefficient of linear trends in the dose dependence of stiffness constants on infusion was 2.98 × 10<sup>-4</sup> in rats with cardiomyopathy and -0.014 × 10<sup>-4</sup> in control animals. Thus, DOX cardiomyopathy led to an increase in the diastolic stiffness constants against the background of DBA treatment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

DOX-Induced Myopathy and Diastolic Stiffness of the Left Ventricular Myocardium of Rat Heart under Conditions of Dobutamine Load

  • 期刊论文

  • 发表日期：

    2025年12月1日

查看全文
  • A. A. Abramov,
  • A. V. Prosvirnin,
  • V. L. Lakomkin

摘要

We studied cardiac relaxation disorders on a rat model of DOX-induced cardiomyopathy (DOX, 2 mg/kg/week for 2 weeks). Left ventricular pressure and volume were synchronously recorded in vivo at baseline and under increased doses of dobutamine (DBA, 1-32 μg/kg/min). Left ventricular diastolic stiffness constants were calculated; the dose dependence of HR and isovolumic relaxation time (tau) was evaluated. In rats with cardiomyopathy, the diastolic stiffness constants increased with increasing the DBA doses, which was absent in the control; HR and tau showed opposite changes. The mean angular coefficient of linear trends in the dose dependence of stiffness constants on infusion was 2.98 × 10-4 in rats with cardiomyopathy and -0.014 × 10-4 in control animals. Thus, DOX cardiomyopathy led to an increase in the diastolic stiffness constants against the background of DBA treatment.