Scholarlink

<p>Polyhydroxylated fullerenes (fullerenols) C<sub>60</sub>(OH)<sub>n</sub> are allotropes of carbon with promising biomedical applications due to their hydrophilicity, chemical stability, and low toxicity profile. We studied the biocompatibility of fullerenol C<sub>60</sub>(OH)<sub>22-24</sub> with human peripheral blood T and B lymphocytes and adhesion/internalization fullerenol by these cells. A mild cytotoxic effect on T cells was found only at high (100 and 200 μg/ml) concentrations of fullerenol (cell viability decreased by 1-2.5%), whereas B cells were resistant to its cytotoxic effects. Interestingly, the absolute number of viable T cells increased after 72-h incubation with high fullerenol concentrations (50, 100, and 200 μg/ml). We also observed active time- and concentration-dependent adhesion/internalization of fullerenol nanoparticles by lymphocytes, especially B cells. Thus, preliminary evaluation of the immunotoxic potential of fullerenol C<sub>60</sub>(OH)<sub>22-24</sub> toward T and B lymphocytes derived from human peripheral blood was performed.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evaluation of Immunotoxicity of Fullerenol C60(OH)22-24 on Human Peripheral Blood T and B Lymphocytes

  • 期刊论文

  • 发表日期：

    2025年11月1日

查看全文
  • M. S. Bochkova,
  • V. P. Timganova,
  • D. I. Usanina,
  • S. A. Zamorina,
  • M. B. Rayev

摘要

Polyhydroxylated fullerenes (fullerenols) C60(OH)n are allotropes of carbon with promising biomedical applications due to their hydrophilicity, chemical stability, and low toxicity profile. We studied the biocompatibility of fullerenol C60(OH)22-24 with human peripheral blood T and B lymphocytes and adhesion/internalization fullerenol by these cells. A mild cytotoxic effect on T cells was found only at high (100 and 200 μg/ml) concentrations of fullerenol (cell viability decreased by 1-2.5%), whereas B cells were resistant to its cytotoxic effects. Interestingly, the absolute number of viable T cells increased after 72-h incubation with high fullerenol concentrations (50, 100, and 200 μg/ml). We also observed active time- and concentration-dependent adhesion/internalization of fullerenol nanoparticles by lymphocytes, especially B cells. Thus, preliminary evaluation of the immunotoxic potential of fullerenol C60(OH)22-24 toward T and B lymphocytes derived from human peripheral blood was performed.