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<p>The efficacy of drug carriers based on submicron vaterite particles in mitigating doxorubicin-induced liver damage was evaluated. The use of alginate-coated vaterite particles significantly reduced hepatic transaminase levels in rats in comparison with the control group, which received doxorubicin encapsulated in PEG-coated carriers. The incorporation of pH-sensitive vaterite carriers enabled stable retention of doxorubicin, thereby minimizing its off-target release and attenuating hepatotoxicity. These findings demonstrate the potential of alginate-coated vaterite particles to reduce the systemic toxicity associated with doxorubicin chemotherapy and highlight their promise as a platform for developing safer, more effective anticancer therapies with improved therapeutic indices.</p>

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Efficacy of Submicron Vaterite-Based Drug Carriers in Mitigating Doxorubicin-Induced Liver Injury

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • A. O. Kuznetsov,
  • Yu. N. Vlasicheva,
  • A. N. Ivanov,
  • E. V. Lengert,
  • A. V. Ermakov

摘要

The efficacy of drug carriers based on submicron vaterite particles in mitigating doxorubicin-induced liver damage was evaluated. The use of alginate-coated vaterite particles significantly reduced hepatic transaminase levels in rats in comparison with the control group, which received doxorubicin encapsulated in PEG-coated carriers. The incorporation of pH-sensitive vaterite carriers enabled stable retention of doxorubicin, thereby minimizing its off-target release and attenuating hepatotoxicity. These findings demonstrate the potential of alginate-coated vaterite particles to reduce the systemic toxicity associated with doxorubicin chemotherapy and highlight their promise as a platform for developing safer, more effective anticancer therapies with improved therapeutic indices.